Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

نویسندگان

  • Edmunds Lukevics
  • Edgars Abele
  • Pavel Arsenyan
  • Ramona Abele
  • Kira Rubina
  • Irina Shestakova
  • Ilona Domracheva
  • Violetta Vologdina
چکیده

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.

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عنوان ژورنال:
  • Metal-Based Drugs

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2002